Fei Ling

Evidence that genome editing is preferable to transgenesis forenhancing animal traits

This study compares transgenesis and genome editing across 72 species and 55 genes to assess their effectiveness in enhancing animal production traits, finding gene editing more impactful overall.

SPIN-CGNN: Improved fixed backbone protein design with contact map-based graph construction and contact graph neural network

This paper introduces SPIN-CGNN, a protein design method using contact maps and graph neural networks, showing improved sequence recovery and structural accuracy compared to existing methods.

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

This study identifies six new genetic variants associated with major adverse cardiovascular events in ACS patients on dual antiplatelet therapy and develops a predictive classifier for MACE.

Spatially resolved gene regulatory and disease vulnerability map of the adult Macaque cortex

The paper integrates single-cell ATAC and transcriptomic data with spatial transcriptomics to map regulatory features and disease vulnerabilities in macaque cortex.

Accelerated DNA evolution in rats is driven by differential methylation in sperm

The paper investigates epigenetic and DNA variation in rat subspecies, finding that differential methylation in sperm drives accelerated DNA evolution through environment-associated chromatin changes.