Cancer BiologyeLifePeer-reviewed
NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model
Ismail Mustafa Meraz, Mourad Majidi, Renduo Song…·Jack A. Roth
This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.
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