Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease
Rhyomi C. Sellnow, Kathy Steece‐Collier, Feras Altwal, Ivette M. Sandoval, Jeffrey H. Kordower, Timothy J. Collier, Caryl E. Sortwell, Anthony R. West, Fredric P. Manfredsson
This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.
Journal of Neuroscience · Apr 1, 2020Peer-reviewedNeuroscience