Molecular BiologybioRxivPreprint
Painless Nav1.7 mutations reveal function-critical residuesin the outer vestibule and N-terminus
Nivedita Sarveswaran, Ichrak Drissi, Samiha S. Shaikh…·Geoff Woods
The paper functionally characterizes six SCN9A missense variants associated with CIP, revealing that they cause complete loss-of-function through structural changes in the extracellular vestibule, ion selectivity filter, and N-terminus.
DOI 10.1101/2025.05.12.653536