NeurosciencebioRxivPreprint
Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids
Shijie Wang, Kaela Kelly, Nathalie Schussler…·Andrew B. West
This study identifies biofluid markers of LRRK2 inhibition in non-human primates using three LRRK2 inhibitors, showing reduced pS935-LRRK2 and exosome LRRK2 in blood, urine, and CSF.
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