Cancer BiologybioRxivPreprint
An NAMPT Inhibitor Decreases NAMPT Capture by an Antibody Directed against the 5-Phosphoribosyl-1-Pyrophosphate-Binding Loop: A Rational for an NAMPT Occupancy Assay
Maysoun Shomali, Sandrine Hilairet, Marianne Duhamel…·Monsif Bouaboula
This paper shows that an NAMPT inhibitor-RP adduct reduces NAMPT capture by an antibody targeting the PRPP-binding loop, enabling a method to assess NAMPT occupancy and correlate it with NAD levels and drug efficacy.
DOI 10.1101/2024.12.11.628028