Cancer BiologybioRxivPreprint
Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms
Rasika Venkataraman, Noemi Puccio, Tun‐Yun Hsueh…·Stanley Chun-Wei Lee
This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.
DOI 10.64898/2026.09.23.753593