MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function
A. Sugiura, G. Andrejeva, K. Voss, D. R. Heintzman, K. L. Beier, M. M. Wolf, D. L. Greenwood, X. Ye, S. K. Shahi, S. N. Freedman, A. M. Cameron, P. Foerch, T. Bourne, X. Xu, J. C. Garcia-Canaveras, , J. Rathmell
This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.
bioRxiv · Feb 3, 2021Immunology