X. Ye

Role of ACSBG1 in brain lipid metabolism and X-linked adrenoleukodystrophy pathogenesis: Insights from a knockout mouse model

This study investigates ACSBG1's role in brain lipid metabolism and XALD using a knockout mouse model, revealing altered fatty acid profiles but no direct link to XALD pathology.

Transformer-based modeling of Clonal Selection and Expression Dynamics (TraCSED) reveals resistance signatures in breast cancer

TraCSED identifies resistance pathways in breast cancer by analyzing scRNA-seq data and clonal selection dynamics over time.

Protein Editing using a Concerted Transposition Reaction

This paper introduces a method to replace internal protein regions in vitro using split inteins, enabling efficient protein semisynthesis under native folding conditions.

Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.

Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1

This study presents cryo-EM structures of MCHR1 in active and inactive states, revealing ligand recognition and activation mechanisms to aid drug development.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps

This study identifies genomic signatures of yolk loss in parasitoid wasps, showing independent Vg gene loss events and associated functional biases in related genes.

Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students

This study examines how fructooligosaccharides and Saccharomyces boulardii affect gut microbiota structure and metabolism in students using an in vitro model, finding that their combination has unique benefits.

Exploratory study of pulsed electric field ablation on atherosclerotic plaque in a rabbit model

This study investigates pulsed electric field ablation's effects on atherosclerotic plaques in rabbits, finding reduced lipid deposition, vascular remodeling, and increased elasticity.

The heparin-binding domain of VEGF165 directly binds to integrin αvβ3 and plays a critical role in signaling.

This study identifies the heparin-binding domain of VEGF165 as critical for integrin αvβ3 binding and signaling, showing its role in mitogenic activity.

One-pot virus detection based on isothermal amplificationcoupled with temperature-activated argonaute

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

Archaeal self-activating GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

This paper investigates the structural dynamics of archaeal GPN-loop GTPases, revealing a lock-switch-rock mechanism for GTP hydrolysis and its functional impact on archaeal motility.

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

The paper shows that androgen signaling reduces glutaminolysis in male Th17 cells, leading to sex-specific metabolic differences that affect Th17-mediated inflammation.

Constitutive protein degradation induces acute cell death via proteolysis products

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

Rapid generation of CD19 CAR-T Cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia

This study develops a method using minicircle DNA to rapidly generate CD19 CAR-T cells that are effective and safe, avoiding genomic integration risks.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

Spatiotemporal coordination of stem cell behavior following alveolar injury

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

The efficiency of p27 peptide cleavage during in vitro respiratory syncytial virus (RSV) infection is cell line and RSV subtype dependent

This study shows that p27 peptide cleavage efficiency of RSV F protein varies by RSV subtype and cell line, affecting pre-F conformation stability during temperature stress.

Integrative multispecies omics reveals a hierarchy of cold-responsive regulatory network launched by circadian components in rosids

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.

A genetically encoded photo-proximity labeling approach for mapping protein territories

This paper introduces a photo-proximity labeling system using visible light to capture protein interactomes with high temporal resolution and correlates it with imaging and proteomics.

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

Crystal Structure of Caskin1/CASK complex reveals the molecular basis of the binding specificity of CASK_CAMK domain and its binding partners

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

Two distinct binding modes provide the RNA binding protein RbFox with extraordinary sequence specificity

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

Dissecting the subtropical adaptation traits and cuticle synthesis pathways via the genome of the subtropical blueberry Vaccinium darrowii

This paper reports the genome assembly of Vaccinium darrowii, identifies adaptation traits, and delineates cuticle biosynthesis pathways to aid blueberry breeding.

Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.