Author

G. Aviles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

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Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Kampmann· 2 shared X. Guo· 2 shared A. P. Wiita· 1 shared B. A. Unger· 1 shared J. D. Rosarda· 1 shared K. R. Baron· 1 shared K. Xu· 1 shared L. Wiseman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

M. Kampmann

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2 papers

Recent·Most cited

Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells

V. Perea, K. R. Baron, V. Dolina, G. Aviles, J. D. Rosarda, X. Guo, M. Kampmann, L. Wiseman

This study shows that halofuginone can compensate for PERK signaling deficiencies by promoting adaptive mitochondrial remodeling, while BtdCPU causes mitochondrial fragmentation.

bioRxiv · Mar 11, 2023Cell Biology

Mitochondrial dysfunction is signaled to the integrated stress response by OMA1, DELE1 and HRI

X. Guo, G. Aviles, Y. Liu, R. Tian, B. A. Unger, Y.-H. T. Lin, A. P. Wiita, K. Xu, M. A. Correia, M. Kampmann

The paper identifies OMA1, DELE1, and HRI as a pathway that relays mitochondrial dysfunction to the integrated stress response, showing its role in activating eIF2 kinase activity and potential therapeutic relevance.

bioRxiv · Jul 26, 2019Cell Biology