X. Guo

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

Contrast-enhanced photon-counting micro-CT of tumor xenograft models

This study evaluates contrast agents for photon-counting micro-CT in tumor xenografts, finding that Exitrone Nano 12000 provides better vasculature enhancement and consistency compared to ISOVUE-370.

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapy

This study shows short-term statin treatment reduces chronic vascular injury from radiation therapy in mice, while long-term treatment fully reverses it.

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Coaching ribosome biogenesis from the nuclear periphery

This study shows that nuclear invaginations regulate ribosome biogenesis by contacting nucleoli, with high curvature increasing ribosome production and low curvature reducing it.

Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention

This study shows licochalcone A suppresses breast cancer growth by targeting SREBP1-dependent lipogenesis and inflammation.

Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH

The paper identifies L3HYPDH as an IFN-stimulated gene that inhibits EV71 replication by targeting its IRES-mediated translation.

PARP14 inhibits the inflammatory response of macrophages through the NF-κB pathway

This study shows PARP14 inhibits macrophage inflammatory responses by suppressing the NF-κB pathway, as demonstrated through genetic knockout and pharmacological inhibition.

Social interactions are impacted by food availability, food type, and group size

The paper examines how group size, food availability, and food type affect social interaction networks in ants, finding increased compartmentalization with larger groups and limited storable food.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma

This study identifies ATP13A3 as a polyamine transporter mediating DFMO-induced polyamine uptake in neuroblastoma, highlighting it as a therapeutic target.

Antibiotics affect the pharmacokinetics of n-butylphthalide in vivo by altering the intestinal microbiota

This study shows antibiotics alter NBP pharmacokinetics in rats by changing intestinal microbiota and reducing CYP3A1 expression.

Climate change impacts dryland multifunctionality: A cascade of precipitation variability to species replacement in multitrophic microbiota

This study examines how precipitation variability impacts soil multifunctionality in drylands through changes in microbial communities, revealing cascading effects on ecosystem function.

Aalbo1200: global genetic differentiation and variability of the mosquito Aedes albopictus

This study generates whole genome sequencing data from Aedes albopictus populations to analyze genetic differentiation and variability across tropical and temperate regions.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

Evolution of a large periplasmic disk in Campylobacterota flagella facilitated efficient motility alongside autoagglutination

The paper investigates the function of a large periplasmic disk in Campylobacter jejuni flagella, showing it facilitates motility and autoagglutination by bracing the motor during filament disentanglement.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7

This study shows ZIP7 enhances ERAD by supplying cytosolic Zn2+ for Rpn11 deubiquitination, rescuing vision loss in Drosophila with misfolded rhodopsin.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

MORE IS DIFFERENT: DRUG PROPERTY ANALYSIS ON CELLULAR HIGH-CONTENT IMAGES USING DEEP LEARNING

The paper introduces MID, a deep learning method for high-content image analysis that outperforms existing tools in drug toxicity classification and compound identification.

Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells

This study shows that halofuginone can compensate for PERK signaling deficiencies by promoting adaptive mitochondrial remodeling, while BtdCPU causes mitochondrial fragmentation.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

A unified classification system for HIV-1 5' long terminal repeats

This paper establishes a unified classification system for HIV-1 5' LTRs using public database sequences, revealing recombination events that alter transcription factor binding sites in 6 out of 22 tested strains.