G. Bertolin

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

Aurora kinase A/AURKA interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death

This study shows that AURKA interacts with mitochondrial Complex V subunits to regulate energy metabolism and cell death in breast cancer cells, with distinct effects based on metabolic preferences.

The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells

The paper develops a FRET biosensor to monitor ATG4B's role in LC3B priming during autophagy, revealing spatial dynamics and inhibitor effects.

tdLanYFP, a yellow, bright, photostable and pH insensitive fluorescent protein for live cell imaging and FRET-based sensing strategies

Quantitative dSTORM super-resolution microscopy localizes Aurora kinase A/AURKA in the mitochondrial matrix

This study uses dSTORM and GcoPS to quantify AURKA localization in the mitochondrial matrix and shows methanol-based fixation improves detection.

Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2

This study identifies AURKA's role in inducing mitophagy via a tripartite complex with PHB2 and MAP1LC3, and shows that Xanthohumol can block this process.

Optimised FRET pairs and quantification approaches to detect the activation of Aurora kinase A at mitosis

This paper develops optimized FRET biosensors to detect Aurora kinase A activation during mitosis with improved sensitivity and multiplexing capabilities.