U. Singh

A pan-tissue, pan-disease compendium of human orphan genes

The paper identifies thousands of human orphan genes from RNA-Seq data, validates them with single-cell RNA-seq, and provides a compendium for future research.

Proteomic analysis of gut in Labeo rohita reveals ECM as Key Player in host's Response to Aeromonas hydrophila Infection

This study identifies ECM proteins as key players in Labeo rohita's immune response to Aeromonas hydrophila infection through proteomic analysis of gut tissue.

Red Fluorescent Carbon Nanoparticles Derived from Spinacia oleracea L.: A Versatile Tool for Bioimaging & Biomedical Applications

This study synthesizes red fluorescent carbon nanoparticles from spinach leaves and demonstrates their bioimaging potential and effects on cell proliferation and migration.

Psidium guajava derived carbon nanoparticles: A promising red emissive cellular bioimaging agent

This study synthesizes red-emitting carbon nanoparticles from guava leaves and demonstrates their biocompatibility and potential for bioimaging applications.

Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker

The paper designs and tests novel viral microbial source tracking markers based on ToBRFV genomes, finding they are sensitive, specific, and more prevalent in human stool and wastewater than existing markers.

Novel class of yellow emitting carbon dots stimulate collective cell migration and 3D uptake in vivo

The paper presents nitrogen-doped yellow fluorescent carbon dots with stable fluorescence and efficient uptake by mammalian cells and zebrafish larvae, showing potential for bioimaging and biomedical applications.

Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

Stress response in Entamoeba histolytica is associated with robust processing of tRNA to tRNA-halves

This study identifies tRNA-derived fragments in Entamoeba histolytica, showing their accumulation under stress and during encystation, and their association with Argonaute proteins.

Water soluble, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

The paper describes red-emitting carbon nanoparticles that are taken up by cells via clathrin-mediated endocytosis and promote 3D cell invasion.

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

tdLanYFP, a yellow, bright, photostable and pH insensitive fluorescent protein for live cell imaging and FRET-based sensing strategies

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

The paper identifies Givinostat as a direct inhibitor of CGGBP1-DNA interaction, expanding its known mechanism beyond HDAC inhibition.

Overexpressed Nup88 stabilized through interaction with Nup62 promotes NFκB dependent pathways in cancer

The paper shows that overexpressed Nup88, stabilized by its interaction with Nup62, promotes NFκB-dependent pathways in head and neck cancer, enhancing cell proliferation and migration.

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.