Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
E. Louka, B. Povinelli, A. Rodriguez Meira, G. Buck, N. Ashley, A. Hamblin, C. A. G. Booth, N. Sousos, A. Roy, N. Elliott, D. Iskander, J. De la Fuente, N. Fordham, S. O'Byrne, S. Inglott, , A. Mead
This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.
bioRxiv · May 7, 2019Cancer Biology