Author

D. Iskander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

I. Roberts· 3 shared A. Rodriguez Meira· 2 shared N. Sousos· 2 shared A. Chaidos· 1 shared A. Hamblin· 1 shared A. J. Mead· 1 shared A. Karadimitris· 1 shared A. Katsarou· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

I. Roberts

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Author profile →

3 papers

Recent·Most cited

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

K. Ponnusamy, M. M. Tzioni, M. Begum, M. E. Robinson, V. S. Caputo, A. Katsarou, N. Trasanidis, X. Xiao, I. V. Kostopoulos, D. Iskander, I. Roberts, P. Trivedi, H. W. Auner, K. Naresh, A. Chaidos, A. Karadimitris

The paper shows that the ZBP1-IRF3 axis promotes myeloma cell proliferation by activating cell cycle genes instead of type I IFN responses.

bioRxiv · Jun 17, 2020Cancer Biology

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

B. Psaila, G. Wang, A. Rodriguez Meira, E. F. Heuston, R. Li, J. O'Sullivan, N. Sousos, S. Anderson, Y. Senis, O. Weinberg, M. L. Callicchio, NIH Intramural Sequencing Core, D. Iskander, D. Royston, D. Milojkovic, , A. J. Mead

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

bioRxiv · May 20, 2019Cancer Biology

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

E. Louka, B. Povinelli, A. Rodriguez Meira, G. Buck, N. Ashley, A. Hamblin, C. A. G. Booth, N. Sousos, A. Roy, N. Elliott, D. Iskander, J. De la Fuente, N. Fordham, S. O'Byrne, S. Inglott, , A. Mead

This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.

bioRxiv · May 7, 2019Cancer Biology