Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis
B. S. Sahu, M. Razzoli, S. McGonigle, J. P. Pallais, M. Nguyen, M. Sadahiro, C. Jiang, W.-J. Lin, K. Kelley, P. Rodriguez, R. Mansk, C. Cero, G. Caviola, P. Palanza, L. Rao, , A. Bartolomucci
This study creates a mouse model with a selective knockout of the TLQP-21 neuropeptide, revealing its role in temperature-dependent resistance to diet-induced obesity and brown adipose tissue activation.
bioRxiv · Mar 23, 2023Physiology