Author

G. Devonshire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. C. Fitzgerald· 3 shared S. Jammula· 2 shared X. Li· 2 shared A. Acha-Sagrado· 1 shared A. Bichisecchi· 1 shared A. Freeman· 1 shared A. M. Frankell· 1 shared A. Mendez· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

R. C. Fitzgerald

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Author profile →

4 papers

Recent·Most cited

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer

P. Ganguli, C. Colomina-Basanta, A. Acha-Sagrado, H. Misetic, M. Armero-Pineiro, A. Mendez, A. Zahra, G. Devonshire, G. Kelly, A. Freeman, M. Green, E. Nye, A. Bichisecchi, P. Bonfanti, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, , F. D. Ciccarelli

The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.

bioRxiv · Jan 24, 2024 · PreprintCancer Biology

Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments

S. J. Scott, X. Li, S. Jammula, G. Devonshire, C. Lindon, R. C. Fitzgerald, P. P. D'Avino

This study identifies mitotic slippage due to defective chromosome attachments as the origin of polyploidy in esophageal adenocarcinoma.

bioRxiv · May 14, 2020Cancer Biology

THE ROLE OF POTASSIUM CHANNELS IN THE PATHOGENESIS OF GASTROINTESTINAL CANCERS AND THERAPEUTIC POTENTIAL

D. Shorthouse, J. L. Zhuang, E. Rahrmann, C. Kosmidou, K. W. Rahrmann, M. W. J. Hall, B. Greenwood, G. Devonshire, R. Gilbertson, R. Fitzgerald, B. A. Hall

The paper identifies KCNQ channel mutations in 30% of gastrointestinal cancers and shows their therapeutic targetability through drug sensitivity and proliferation inhibition.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology

The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic

A. M. Frankell, S. Jammula, X. Li, G. Contino, S. S. Killcoyne, S. Abbas, J. Perner, L. Bower, G. Devonshire, E. Ococks, N. Grehan, J. Mok, M. O'Donovan, S. Macrae, M. Eldridge, , The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium

This study identifies 77 driver genes and 21 non-coding driver elements in 551 Esophageal Adenocarcinomas, linking them to clinical outcomes and therapeutic targets.

bioRxiv · Aug 15, 2018Cancer Biology