Author

E. Nye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. D. Ciccarelli· 2 shared J. Spencer· 2 shared M. Rodriguez-Justo· 2 shared A. Acha-Sagrado· 1 shared A. Acha-Sagredo· 1 shared A. Behrens· 1 shared A. Bichisecchi· 1 shared A. Damianou· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

F. D. Ciccarelli

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3 papers

Recent·Most cited

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of oesophageal cancer

P. Ganguli, C. Colomina-Basanta, A. Acha-Sagrado, H. Misetic, M. Armero-Pineiro, A. Mendez, A. Zahra, G. Devonshire, G. Kelly, A. Freeman, M. Green, E. Nye, A. Bichisecchi, P. Bonfanti, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, , F. D. Ciccarelli

The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.

bioRxiv · Jan 24, 2024 · PreprintCancer Biology

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

M. Bortolomeazzi, M. R. Keddar, L. Montorsi, A. Acha-Sagredo, L. Benedetti, D. Temelkovski, S. Choi, N. Petrov, K. Todd, P. Wai, J. Kohl, T. Denner, E. Nye, R. Goldstone, S. Ward, , F. D. Ciccarelli

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

bioRxiv · Dec 15, 2020 · PreprintCancer Biology

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

E. J. Ruiz, A. Pinto-Fernandez, A. P. Turnbull, L. Lan, T. M. Charlton, H. C. Scott, A. Damianou, G. Vere, E. M. Riising, C. Da Costa, W. W. Krajewski, D. Guerin, J. Kearns, S. Ioannidis, M. Katz, , A. Behrens

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

bioRxiv · Nov 17, 2020Cancer Biology