G. Frati

Safety and efficacy study of CRISPR/Cas9 treatment of sickle cell disease in clinically relevant conditions highlights disease-specific response

This study evaluates the safety and efficacy of CRISPR/Cas9-mediated HbF reactivation in sickle cell disease by testing it in patient-derived HSPCs and shows it is effective but has off-target effects.

Investigating the risk of cardiac fibrosis due to heat-not-burn cigarettes through human cardiac stromal cells

This study examines how serum from chronic heat-not-burn cigarette smokers affects cardiac stromal cells, showing increased fibrosis and reduced paracrine support.

Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126

This study shows that platelet lysate-derived extracellular vesicles enhance angiogenesis via miR-126, without relying on VEGF.