Author

P. Antoniou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

A. Chalumeau· 1 shared A. Miccio· 1 shared A.-L. Loyd· 1 shared B. MLAYAH· 1 shared E. Gordon· 1 shared G. Frati· 1 shared G. Hardouin· 1 shared G. Sartre· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

A. Chalumeau

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Author profile →

2 papers

Recent·Most cited

Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering

P. Antoniou, L. Dacquay, N. Selfjord, K. Madeyski-Bengtson, A.-L. Loyd, E. Gordon, G. Thom, P.-P. Hsieh, S. Wimberger, S. Svikovic, M. Firth, N. Akrap, M. Maresca, M. Peterka

This paper improves prime editing by modulating DNA repair pathways and engineering pegRNA, achieving higher precision and efficiency in human and mouse cells.

bioRxiv · Feb 1, 2024 · PreprintBioengineering

Safety and efficacy study of CRISPR/Cas9 treatment of sickle cell disease in clinically relevant conditions highlights disease-specific response

G. Frati, M. Brusson, G. Sartre, B. MLAYAH, T. FELIX, A. Chalumeau, P. Antoniou, G. Hardouin, J.-P. Concordet, O. Romano, G. Turchiano, A. Miccio

This study evaluates the safety and efficacy of CRISPR/Cas9-mediated HbF reactivation in sickle cell disease by testing it in patient-derived HSPCs and shows it is effective but has off-target effects.

bioRxiv · Jan 14, 2024Bioengineering