Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia
L. M. Heltemes-Harris, G. Hubbard, R. S. LaRue, S. A. Munro, T. P. Knutson, R. Yang, C. M. Henzler, T. K. Starr, A. L. Sarver, s. M. Kornblau, M. A. Farrar
This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.
bioRxiv · Nov 25, 2020Cancer Biology