R. Yang

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories

The paper analyzes nuclear growth variations in hiPS cell colonies, finding context-dependent and inherited mechanisms shaping growth trajectories.

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.

Multiple pathways for licensing human replication origins

This study identifies multiple pathways for human replication origin licensing, revealing redundancy and alternative mechanisms distinct from yeast.

Systematic Identification of UBE2C As a Prognostic Biomarker and Correlated with Immunosuppression and Invasiveness in Glioma

This study identifies UBE2C as a prognostic biomarker in glioma, linked to immunosuppression and invasiveness through IL6/IL10 and MMP pathways.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals - Replacing Colloidal Gold

This paper develops plasmonic nanoparticles made from inexpensive metals for lateral flow assays, showing they perform as well as or better than gold nanoparticles in biosensing.

Comparing multifunctional viral and eukaryotic proteins for generating scission necks in membranes

This study compares the membrane scission capabilities of viral and eukaryotic proteins using mechanical models and SAXS data to analyze how lipid composition and interfacial tension affect neck size.

De novo Design of Peptides that Bind Specific Conformers of α-Synuclein

This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery

This study uses electrical impedance measurements to monitor and predict intracellular delivery efficiency via porous substrate electroporation without fluorescent labels or imaging.

Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

This study identifies Chi3l1 as a host protein that interacts with bacterial peptidoglycan in the gut mucus to regulate microbiota composition and prevent colitis.

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

This study shows BMP signaling maintains auricular chondrocyte identity and prevents microtia by inhibiting PKA, through a switch from chondrogenic to osteogenic programs.

Species- and strain-effects in interferon, innate immunity, and barrier transcriptional response of microbiome interactions of 3D respiratory epithelial cultures

The paper examines how different microbes affect host immune and barrier responses in respiratory epithelial cultures, finding that interferon variability is not linked to microbial diversity or other innate pathways.

Interchromosomal Colocalization with Parental Genes Is Linked to the Function and Evolution of Mammalian Retrocopies

This study shows that retrocopies and their parental genes colocalize in 3D genome organization, leading to increased transcription, translation, and evolutionary conservation.

Targeted inhibition of SCF-SKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

This study shows that inhibiting SKP2 in osteosarcoma reduces tumor growth and improves survival, suggesting it as a potential therapeutic target.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

This study shows SKP2 knockout in osteosarcoma mouse models increases immune infiltration and correlates with improved patient survival.

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

The paper analyzes TAD boundaries across species to show evolutionary conservation and functional significance, finding ultraconserved boundaries have stronger insulation and CTCF binding.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Repurposing clemastine to target glioblastoma cell stemness

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

Notch Signaling and Fluid Shear Stress in Regulating Osteogenic Differentiation

This study investigates how fluid shear stress regulates osteogenic differentiation of hMSCs through Notch signaling using an LNA/DNA nanobiosensor and pharmacological inhibition.

Fatty acid binding protein 1 and fatty acid synthetase overexpression have differential effects on collagen III and cross-linking in Zongdihua pig tissues

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

Analysis and Identification of Necroptosis Landscape on Therapy and Prognosis in Bladder Cancer

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

Co-expression of recombinant human collagen α1(III) chain with viral prolyl 4-Hydroxylase in P. pastoris GS115

This study co-expresses recombinant human collagen α1(III) chain with viral prolyl 4-hydroxylase in P. pastoris GS115 and confirms successful expression and secretion of the hydroxylated collagen.

A genetic model for in vivo proximity labeling of the mammalian secretome

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

Probing Notch1-Dll4 Signaling in Regulating Osteogenic Differentiation of Human Mesenchymal Stem Cells using Single Cell Nanobiosensor

This study uses a LNA/DNA nanobiosensor to analyze Dll4 mRNA dynamics during osteogenic differentiation of hMSCs in 2D and 3D environments, showing Notch1-Dll4 signaling regulates osteogenesis and is active during differentiation.