Author

A. L. Sarver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 7

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Assay:bulk RNA-seq· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3

Frequent Co-Authors

J. F. Modiano· 4 shared A. J. Schulte· 2 shared C. L. Foster· 2 shared I. Cornax· 2 shared J. H. Kim· 2 shared K. Lindblad-Toh· 2 shared L. J. Mills· 2 shared L. Oseth· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

J. F. Modiano

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7 papers

Recent·Most cited

Neoadjuvant systemic oncolytic vesicular stomatitis virus is safe and may enhance long-term survivorship in dogs with naturally occurring osteosarcoma.

K. M. Makielski, A. L. Sarver, M. S. Henson, K. M. Stuebner, A. Borgatti, L. Suksanpaisan, C. Preusser, A.-F. Tabaran, I. Cornax, M. G. O'Sullivan, A. Chehadeh, D. Groschen, K. Bergsrud, S. Pracht, A. Winter, , S. Naik

This study evaluates neoadjuvant oncolytic virus therapy in dogs with osteosarcoma, finding it safe and associated with increased long-term survivorship and immune gene expression.

bioRxiv · Apr 16, 2023Cancer Biology

Differential migration mechanics and immune responses of glioblastoma subtypes

G. A. Shamsan, C. J. Liu, B. C. Braman, R. Li, S. K. Rathe, A. L. Sarver, N. Ghaderi, M. M. McMahon, R. L. Klank, B. R. Tschida, S. J. McFarren, P. C. Rosato, D. Masopust, J. N. Sarkaria, H. B. Clark, , D. J. Odde

This study shows mesenchymal glioblastoma cells migrate faster and generate more traction force than proneural cells, but their immunologically hot environment improves survival despite aggressive growth.

bioRxiv · Jun 26, 2022 · PreprintCancer Biology

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

J. H. Kim, A. J. Schulte, A. L. Sarver, M. G. Angelos, A. M. Frantz, C. L. Foster, T. D. O'Brien, I. Cornax, M. G. O'Sullivan, N. Cheng, M. Lewellen, L. Oseth, S. Kumar, S. Bullman, C. S. Pedamallu, , J. F. Modiano

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

bioRxiv · May 21, 2021Cancer Biology

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

J. Li, M. M. Kaneda, J. Ma, M. Li, K. Patel, T. Koga, A. L. Sarver, F. Furnari, B. Xu, S. Dhawan, J. Ning, H. Zhu, A. Wu, G. You, T. Jiang, , C. C. Chen

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

Proceedings of the National Academy of Sciences · Apr 12, 2021Peer-reviewedCancer Biology

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia

L. M. Heltemes-Harris, G. Hubbard, R. S. LaRue, S. A. Munro, T. P. Knutson, R. Yang, C. M. Henzler, T. K. Starr, A. L. Sarver, s. M. Kornblau, M. A. Farrar

This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.

bioRxiv · Nov 25, 2020Cancer Biology

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

J. H. Kim, K. J. Megquier, R. Thomas, A. L. Sarver, J. M. Song, Y. T. Kim, A. J. Schulte, N. Cheng, M. A. Linden, P. Murugan, L. Oseth, C. L. Foster, I. Elvers, R. Swofford, J. Turner-Maier, , J. F. Modiano

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

bioRxiv · Aug 11, 2020Cancer Biology

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma

L. J. Mills, M. Scott, P. Shah, A. R. Cunanan, A. Deshpande, B. Auch, B. Curtin, K. B. Beckman, L. G. Spector, A. L. Sarver, S. Subramanian, T. Richmond, J. F. Modiano

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.

bioRxiv · Apr 29, 2020Cancer Biology