Author

G. Iyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

R. J. Kimple· 2 shared A. Boire· 1 shared A. Cercek· 1 shared A. Durmaz· 1 shared A. L. Ho· 1 shared A. Luthra· 1 shared A. M. Baschnagel· 1 shared A. N. Shoushtari· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

R. J. Kimple

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Author profile →

3 papers

Recent·Most cited

Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response

A. Rao, Z. Ni, D. Suresh, C. Mohanty, A. Wang, D. Lee, K. Nickel, S. Varambally, R. J. Kimple, P. F. Lambert, C. Kendziorski, G. Iyer

This study shows BET inhibition reduces E6 and E7 expression in HPV-16 HNSCC, with variable effects on p53 and Rb, and induces G1 arrest and apoptosis.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

B. Nguyen, C. Fong, A. Luthra, S. A. Smith, R. G. DiNatale, S. Nandakumar, H. Walch, W. K. Chatila, R. Madupuri, R. Kundra, C. M. Bielski, B. Mastrogiacomo, A. Boire, S. Chandarlapaty, K. Ganesh, , Varghes

The paper analyzes genomic data from 25,000 patients to identify associations between genomic alterations and metastatic patterns across 50 tumor types, finding chromosomal instability correlates with metastatic burden in some cancers.

bioRxiv · Jun 28, 2021Cancer Biology

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

A. M. Baschnagel, S. Kaushik, A. Durmaz, S. Goldstein, I. M. Ong, L. Abel, P. A. Clark, T. Leal, D. Buehler, G. Iyer, J. G. Scott, R. J. Kimple

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

bioRxiv · Jun 2, 2020Cancer Biology