G. Jogl

High-Fidelity, Hyper-Accurate, and Evolved Mutants Rewire Atomic Level Communication in CRISPR-Cas9

The paper investigates how specific mutations in the Rec3 domain of CRISPR-Cas9 variants affect structural dynamics and allosteric communication to enhance specificity.

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

This study identifies and characterizes small molecule inhibitors of the LINE-1 retrotransposon endonuclease, showing they reduce DNA damage and inflammation in senescent cells.

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

This paper shows that the N-terminus and coiled-coil domain of ORF1 protein mediate phase separation, which may protect L1 transcripts from degradation.

Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics

This study uses NMR and GaMD simulations to investigate allosteric motions in the CRISPR-Cas9 HNH nuclease, revealing a dynamic pathway involved in DNA cleavage activation.