Author

E. Skeens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:mechanistic / dynamical model· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

G. P. Lisi· 3 shared G. Jogl· 2 shared G. Palermo· 2 shared A. Acharya· 1 shared A. M. D'Ordine· 1 shared B. Feng· 1 shared B. Rubenstein· 1 shared D. K. Schweppe· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

G. P. Lisi

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Author profile →

4 papers

Recent·Most cited

High-Fidelity, Hyper-Accurate, and Evolved Mutants Rewire Atomic Level Communication in CRISPR-Cas9

E. Skeens, S. Sinha, M. Ahsan, A. M. D'Ordine, G. Jogl, G. Palermo, G. P. Lisi

The paper investigates how specific mutations in the Rec3 domain of CRISPR-Cas9 variants affect structural dynamics and allosteric communication to enhance specificity.

bioRxiv · Aug 25, 2023 · PreprintBiophysics

Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

E. Skeens, M. M. Gadzuk-Shea, D. Shah, V. Bhandari, D. K. Schweppe, R. B. Berlow, G. P. Lisi

This study investigates how redox conditions affect the structure and function of MIF, identifying redox-sensitive sites that modulate its interaction with CD74.

bioRxiv · Sep 1, 2021Biophysics

A Topological Data Analytic Approach for Discovering Biophysical Signatures in Protein Dynamics

W. S. Tang, G. M. da Silva, H. Kirveslahti, E. Skeens, B. Feng, T. Sudijono, K. K. Yang, S. Mukherjee, B. Rubenstein, L. Crawford

SINATRA Pro identifies topological differences between protein structures from molecular dynamics simulations, revealing both known and novel biophysical signatures with improved resolution.

bioRxiv · Jul 28, 2021Biophysics

Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics

K. W. East, J. C. Newton, U. N. Morzan, A. Acharya, E. Skeens, G. Jogl, V. S. Batista, G. Palermo, G. P. Lisi

This study uses NMR and GaMD simulations to investigate allosteric motions in the CRISPR-Cas9 HNH nuclease, revealing a dynamic pathway involved in DNA cleavage activation.

bioRxiv · Oct 10, 2019Biophysics