Dynamics of human protein kinases linked to drug selectivity
D. Kern, W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. Padua, X. Meniche
The paper investigates whether protein dynamics after drug binding contribute to kinase inhibitor selectivity by analyzing Aurora A kinase interactions with three drugs.
bioRxiv · Mar 21, 2018Cancer Biology