A biophysical framework for double-drugging kinases
C. Kim, H. Ludewig, A. Hadzipasic, S. Kutter, V. Nguyen, D. Kern
This study develops a biophysical framework to analyze double-drugging of kinases, revealing cooperative effects between orthosteric and allosteric inhibitors and providing structural insights.
bioRxiv · Mar 17, 2023Biochemistry