Author

R. Otten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Kern· 6 shared W. Pitsawong· 3 shared R. A. Padua· 2 shared R. V. Agafonov· 2 shared V. Buosi· 2 shared A. Glaser· 1 shared A. M. Ojoawo· 1 shared A. Zorba· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersBiochemistry

D. Kern

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale

H. K. Wayment-Steele, R. Otten, W. Pitsawong, A. M. Ojoawo, A. Glaser, L. A. Calderone, D. Kern

This paper characterizes the conformational landscape of KaiB, revealing its slow interconversion between states and how evolution tunes this process to match circadian rhythms.

bioRxiv · Jun 3, 2024Biochemistry

Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

G. E. Jara, F. Pontiggia, R. Otten, R. V. Agafonov, M. A. Marti, D. Kern

The paper investigates the transition-state ensemble in adenylate kinase, finding a broad set of energetically equivalent configurations that support efficient enzyme catalysis.

bioRxiv · Oct 3, 2023Biophysics

From primordial clocks to circadian oscillators

W. Pitsawong, R. A. Padua, T. Grant, M. Hoemberger, R. Otten, N. Bradshaw, N. Grigorieff, D. Kern

This study investigates the primordial circadian clock in Rhodobacter sphaeroides using structural and kinetic analyses to elucidate its mechanism and evolutionary origins.

bioRxiv · Nov 28, 2022Biochemistry

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

P. Finneran, M. Soucheray, C. Wilson, R. Otten, V. Buosi, N. J. Krogan, D. Swaney, D. Theobald, D. Kern

This study reveals the bimodal evolution of Src and Abl kinase substrate specificity using mammalian cell extract as a substrate pool, showing divergent evolutionary paths leading to specific and promiscuous enzymes.

bioRxiv · Aug 12, 2020 · PreprintBiochemistry

Dynamics of human protein kinases linked to drug selectivity

D. Kern, W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. Padua, X. Meniche

The paper investigates whether protein dynamics after drug binding contribute to kinase inhibitor selectivity by analyzing Aurora A kinase interactions with three drugs.

bioRxiv · Mar 21, 2018Cancer Biology

Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution

R. Otten, L. Liu, L. R. Kenner, M. W. Clarkson, D. Mavor, D. S. Tawfik, D. Kern, J. S. Fraser

This study uses directed evolution to identify mutations that restore catalytic activity in a mutant enzyme, revealing how conformational dynamics are shaped by evolutionary selection.

bioRxiv · Sep 5, 2017Biophysics