Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation
G. L. Garcia, T. Orellana, G. Gorecki, L. G. Frisbie, R. Baruwal, E. Goldfield, I. Beddows, I. P. MacFawn, A. K. Britt, M. M. Hale, H. Shen, R. Buckanovich, T. Finkel, R. Drapkin, T. R. Soong, , L. G. Coffman
This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.
bioRxiv · May 23, 2024 · PreprintCancer Biology