Author

T. Finkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

S. C. Watkins· 2 shared A. J. Nelson· 1 shared A. Roberts· 1 shared A. Sodhi· 1 shared B. Ma· 1 shared C. T. Wallace· 1 shared C. Van't Land· 1 shared C. Yu-Wei· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

S. C. Watkins

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

S. Ghosh, R. Sharma, S. Bammidi, V. Koontz, M. Nemani, M. Yazdankhah, K. M. Kedziora, C. T. Wallace, C. Yu-Wei, J. Franks, D. Bose, D. Rajasundaram, S. Hose, J.-A. Sahel, R. Puertollano, , D. Sinha

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation

H. Wang, J. Lu, T. Stevens, A. Roberts, J. Mandel, R. Avula, B. Ma, Y. Wu, J. Wang, T. Finkel, C. Van't Land, J. E. Vockley, M. Airik, R. Airik, R. Muzumdar, , E. V. Prochownik

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

bioRxiv · Jan 30, 2023 · PreprintCancer Biology

Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses

R. Houston, S. Sekine, M. J. Calderon, F. Seifuddin, G. Wang, H. Kawagishi, D. A. Malide, Y. Li, M. Gucek, M. Pirooznia, A. J. Nelson, M. P. Stokes, J. Stewart-Ornstein, S. G. Wendell, S. C. Watkins, , Y. Sekine

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

bioRxiv · Jan 24, 2020Cell Biology