I. Beddows

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

This study investigates how NF1 deficiency affects metabolic reprogramming in ER+ breast cancer and identifies potential therapeutic synergies between metabolic and targeted inhibitors.

A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

This paper develops a humanized immune stroma PDX model to better reflect therapeutic resistance and patient response to immunotherapies.

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity

This study shows that Nf1 deficiency in rats accelerates mammary development and promotes luminal-basal plasticity and EMT-mediated invasion.

PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression

This study shows that PGC-1β promotes mitochondrial metabolism and suppresses inflammatory gene expression in dendritic cells.

Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development

The paper generates a new Fzd2 flox mouse model to investigate tissue-specific roles of Fzd2, resolving contradictions in previous global knockout studies.

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

Examining the molecular mechanisms contributing to the success of an invasive species across different ecosystems

This study uses RNA-seq to compare molecular processes in invasive Gypsophila paniculata populations across two ecosystems, finding environmental plasticity and limited genetic divergence contribute to their success.

Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor

This paper shows that targeting the SWI/SNF complex with mithramycin and its analogue EC8042 induces epigenetic reprogramming and durable tumor regression in rhabdoid tumors.