H. Shen

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

Gfi1 controls the formation of effector CD8 T cells during chronic infection and cancer

This study shows that Gfi1 regulates the formation of exhausted effector-like CD8 T cells during chronic infection and cancer, impacting their differentiation and function.

Measuring and modeling the dynamics of mitotic error correction

The paper quantifies mitotic error correction dynamics in human cells and validates a model explaining error reduction and anaphase timing.

The Treatment of diarrheal mice with Tenebrio Molitor meal

This study shows that adding Tenebrio molitor meal to the diet of diarrhea mice improves their health by increasing feed intake, reducing diarrhea rates, and enhancing enzyme activities.

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

The paper identifies dual regulation of SLC25A39 by AFG3L2 and iron, showing how this controls mitochondrial glutathione homeostasis in neurons.

GRAMD2+ alveolar type I cell plasticity facilitates cell state transitions in organoid culture

The paper identifies GRAMD2+ alveolar type I cells as plastic and capable of transitioning through multiple lung epithelial cell states in organoid culture.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

This paper develops a humanized immune stroma PDX model to better reflect therapeutic resistance and patient response to immunotherapies.

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

Validation of a multiplex microsphere immunoassay for detection of Trypanosoma cruzi antibodies in dogs

This study validates a multiplex microsphere immunoassay for detecting Trypanosoma cruzi antibodies in dogs, showing 100% sensitivity and 96.97% specificity compared to the indirect fluorescent antibody test.

Identification of two β-cell subtypes by 7 independent criteria

The paper identifies two distinct β-cell subtypes, βHI and βLO, using seven independent criteria and shows that H3K27me3 dosage regulates their ratio in vivo.

Extracellular Vesicles from Inflammation-Primed Adipose-Derived Stem Cells Enhance Achilles Tendon Repair by Reducing Inflammation and Promoting Intrinsic Healing

Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

An efficient context-aware approach for whole slide image classification

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

Alveolar epithelial type 1 cells serve as a cell of origin for lung adenocarcinoma with distinct molecular and phenotypic presentation

This study identifies alveolar epithelial type 1 cells as a potential cell of origin for lung adenocarcinoma, showing distinct molecular and histological features based on cell of origin.

Utah Array Characterization and Histological Analysis of a Multi-Year Implant in Non-Human Primate Motor and Sensory Cortices

The paper characterizes the histological and material changes in a non-human primate brain after long-term Utah array implantation, finding significant neuron loss and electrode damage.

Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M

This study identifies how Plasmodium falciparum proteins hijack human IgM to evade immune responses and cause severe malaria.

Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs

This study investigates the evolutionary adaptations of IRG1 to refine itaconate synthesis and mitigate trade-offs in innate immunometabolism.

PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression

This study shows that PGC-1β promotes mitochondrial metabolism and suppresses inflammatory gene expression in dendritic cells.

The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion

The study shows that a C-terminal fragment of PC1 suppresses cystic disease in a murine model by interacting with a mitochondrial enzyme, affecting metabolism and mitochondrial function.

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

The paper uses CRISPR screening to identify gene-by-gene and gene-by-environment interactions among mitochondrial transporters, revealing SLC25A39's role in mitochondrial glutathione transport.

Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation

This paper develops photosensitized electrospun nanofibrous filters that capture and inactivate airborne coronaviruses under visible light, achieving 99.2% capture and 98.9% inactivation of MHV-A59.

Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting

The paper identifies a pathway called uridinolysis that allows cells to use uridine and RNA-derived ribose to support glycolysis when glucose is limiting.

A lipid-mTORC1 nutrient-sensing pathway regulates animal development by peroxisome-derived hormones

The paper identifies a lipid-mTORC1 pathway regulated by peroxisome-derived hormones that controls development in C. elegans by modulating chemosensory neurons.

Population genomics of Salmonella enterica serovar Weltevreden ST365, an emerging predominant causative agent of diarrheal disease

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

An integrated strategy reveals complex glycosylation of erythropoietin using top-down and bottom-up mass spectrometry

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.