Author

G. Leor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

U. Ben-David· 3 shared J. Zerbib· 2 shared A. A. Schaffer· 1 shared A. D. Sahu· 1 shared A. S. Kadmon· 1 shared C. K. Wong· 1 shared D. Cimini· 1 shared E. D. Shulman· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

U. Ben-David

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3 papers

Recent·Most cited

Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas

N. U. Nair, A. A. Schaffer, M. E. Gertz, K. Cheng, J. Zerbib, A. D. Sahu, G. Leor, E. D. Shulman, K. D. Aldape, U. Ben-David, E. Ruppin

The paper investigates the co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas, finding functional rescue interactions on chromosome 7 that may compensate for chromosome 10 loss.

bioRxiv · Jan 17, 2024 · PreprintCancer Biology

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

J. Zerbib, M. R. Ippolito, Y. Eliezer, G. De Feudis, E. Reuveni, A. S. Kadmon, S. Martin, S. Vigano', G. Leor, J. Berstler, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, U. Ben-David, S. Santaguida

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

bioRxiv · Jan 27, 2023Cancer Biology

Whole-genome duplication shapes the aneuploidy landscape of human cancers

K. Prasad, M. Bloomfield, H. Levi, K. Keuper, S. V. Bernhard, N. C. Baudoin, G. Leor, M. Giam, C. K. Wong, G. Rancati, Z. Storchova, D. Cimini, U. Ben-David

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

bioRxiv · May 5, 2021Cancer Biology