S. Martin

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

Experimental evolution of an RNA virus in Caenorhabditis elegans

This study evolves two Orsay virus strains in C. elegans, finding slight infectivity changes, non-synonymous mutations, and non-random distribution of minor variants in polymorphic regions.

DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen

This study investigates the role of CcrM-mediated DNA methylation in genome maintenance in Agrobacterium tumefaciens, showing its impact on replication and cell cycle regulation.

Algebraic invariants for inferring 4-leaf semi-directed phylogenetic networks

This paper develops an algebraic method to infer 4-leaf semi-directed phylogenetic networks from nucleotide sequences, showing high accuracy on simulated data and application to real Xiphophorus species data.

ATP13A3 Variants Promote Pulmonary Arterial Hypertension by Disrupting Polyamine Transport

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

The lipid flippase ATP10B enables cellular lipid uptake under stress conditions

This study shows that ATP10B, a lipid flippase, enhances cellular phosphatidylcholine uptake under stress conditions like rotenone treatment.

EphrinA4/EphA4 controls blood pressure via arterial sympathetic innervation

This study shows EphrinA4 in arterial SMCs repels sympathetic axons, and its loss increases sympathetic innervation, leading to elevated blood pressure and hypertension under stress.

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.

The gut microbiome has sexually dimorphic effects on bone tissue energy metabolism and multiscale bone quality in C57BL/6J mice

This study shows that the gut microbiome affects bone metabolism and quality differently in male and female mice, with sex-specific changes in metabolism, mineralization, and biomechanics.

Non-random mating between nesting sites of Hawaiian hawksbill turtles: demographic discontinuity within a small isolated population

This study uses genetic markers to analyze mating patterns and demographics of Hawaiian hawksbill turtles, finding non-random mating and demographic discontinuity across nesting sites.

Overground gait adaptability in older adults with diabetes in response to virtual targets and physical obstacles

This study examines gait adaptability in older adults with diabetes, finding they have greater step length errors and reduced toe clearance when adapting to virtual targets and obstacles.

Contribution of hybridization to the evolution of a derived reproductive strategy in ricefishes

The paper investigates the evolution of pelvic-brooding in Sulawesi ricefishes, finding no gene flow between distantly related pelvic-brooding lineages but evidence of ancient hybridization and introgression contributing to the trait.

IRE1 RNase controls CD95-mediated cell death

This study shows that IRE1 RNase activity regulates CD95 expression and cell death in cancer cells, with implications for therapeutic targeting.

Delimiting Continuity: Comparison of Target Enrichment and ddRAD for Delineating Admixing Parapatric Melitaea Butterflies

This study compares target enrichment and ddRAD sequencing in parapatric Melitaea butterflies, finding congruent phylogenetic results and recommending consistent classification of parapatric taxa.

Australia as a global sink for the genetic diversity of avian influenza A virus

This study shows Australia acts as a global sink for avian influenza A virus diversity, with isolated circulation and high reassortment, distinct from Northern Hemisphere patterns.

Mechano-Biochemical Regulation of the C. elegans HMP1-HMP2 protein complex

This study investigates how mechanical tension regulates the stability and function of the HMP1-HMP2 protein complex in C. elegans, revealing its role in mechanotransduction.

Tissue specific targeting of DNA nanodevices in a multicellular living organism

This study demonstrates the targeting of DNA nanodevices to specific cell types in C. elegans using receptor-ligand interactions and biological barriers.

SARS-CoV2 envelop proteins reshape the serological responses of COVID-19 patients

This study examines the immunogenic potential of SARS-CoV-2 envelope proteins, showing that Spike and Membrane proteins elicit specific IgG, IgM, and IgA responses, with reduced Ig binding observed for the Spike G614 variant.

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

This study identifies an EMT-primary cilium-GLIS2 signaling axis that regulates mammary stem cell properties and claudin-low breast tumorigenesis.

DyNeuMo Mk-1: Design and Pilot Validation of an Investigational Motion-Adaptive Neurostimulator with Integrated Chronotherapy

The paper describes the design and validation of a motion-adaptive neurostimulator with chronotherapy, intended for movement disorders and other applications.

Molecular Basis of Far-red Sensing in Cyanobacteriochrome

This study reports the crystal structure of a far-red-sensing cyanobacteriochrome and identifies key protein-chromophore interactions that enable far-red light perception.

Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)

The paper examines how photoperiod affects the transcriptional response to seawater entry in Atlantic salmon, finding that short photoperiod impairs hypo-osmoregulation and alters gill gene expression.

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

The paper uses optogenetics to show that scaffold-mediated positive feedback and Ras GTPase activity are essential for Cdc42 local activation and bipolar growth in fission yeast.

Capping protein insulates Arp2/3-assembled actin patches from formins

The paper shows that capping protein prevents formins from interfering with Arp2/3-assembled actin patches in fission yeast, maintaining their distinct identity and function.

Linalool acts as a fast and reversible anesthetic in Hydra

This study identifies linalool as a safe, fast-acting, and reversible anesthetic for Hydra, enabling repeated in vivo imaging over multiple days without long-term toxicity.

Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size

The paper shows that Pom1 gradients in S. pombe cells are regulated by multi-phosphorylation and clustering, adjusting mid-cell levels based on cell size.

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.

Molecular mechanism of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX

The paper investigates the interaction between IscX and CyaY in bacterial iron-sulfur cluster assembly, showing IscX modulates CyaY's inhibitory effect on cluster formation.