A. A. Schaffer

Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas

The paper investigates the co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas, finding functional rescue interactions on chromosome 7 that may compensate for chromosome 10 loss.

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

Fraction of copy-number alterations significantly predicts survival following immunotherapy in a few cancers

The paper reanalyzes data to assess if tumor aneuploidy score or related metrics predict immunotherapy survival, finding only limited predictive power in a few cancers.

Using a recently approved tumor mutational burden biomarker to stratify patients for immunotherapy may introduce a sex bias

The paper investigates if using a high tumor mutational burden (TMB) threshold for immunotherapy selection introduces sex bias, finding significant bias in melanoma but not in other cancers.

Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types

The paper investigates how immune factors influence the predictive power of tumor mutational burden (TMB) for immunotherapy response across cancer types.

Underground Heterosis for Melons Yield

This study demonstrates root-mediated yield heterosis in melons by grafting common scions onto hybrid rootstocks, showing significant yield improvements over parental lines and commercial varieties.

Melon ethylene-mediated transcriptome and methylome dynamics provide insights to volatile production

This study investigates ethylene's role in melon ripening by analyzing transcriptome and methylome changes, revealing connections between DNA methylation and volatile compound production.

Multi-allelic APRR2 Gene is Associated with Fruit Pigment Accumulation in Melon and Watermelon

This study identifies the multi-allelic APRR2 gene as a key regulator of fruit pigment accumulation in melon and watermelon, demonstrating its role in rind and flesh color variation.