Author

Y. Cohen-Sharir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Laue· 3 shared M. R. Ippolito· 3 shared S. Santaguida· 3 shared U. Ben-David· 3 shared A. S. Kadmon· 2 shared E. Reuveni· 2 shared F. Vazquez· 2 shared G. De Feudis· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

K. Laue

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3 papers

Recent·Most cited

Cancer BiologybioRxivJan 27, 2023

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

J. Zerbib, M. R. Ippolito, Y. Eliezer…·S. Santaguida

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

DOI 10.1038/s41467-024-52176-x

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivJan 27, 2023

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

M. R. Ippolito, J. Zerbib, Y. Eliezer…·U. Ben-David

This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.

DOI 10.1158/2159-8290.cd-23-0309

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivJun 18, 2020

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

Y. Cohen-Sharir, J. M. McFarland, M. Abdusamad…·U. Ben-David

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

DOI 10.1038/s41586-020-03114-6

humanbulk RNA-seq

𝕏 PostBluesky