Molecular chaperones maximize the native state yield per unit time by driving substrates out of equilibrium
S. Chakrabarti, C. Hyeon, X. Ye, G. Lorimer, D. Thirumalai
The paper develops a stochastic model to explain how molecular chaperones maximize native state production rates by driving substrates out of equilibrium, reconciling conflicting experimental results on ribozyme and protein folding.
bioRxiv · Jun 21, 2017Biophysics