S. Chakrabarti

This study identifies dual-specific autophosphorylation in IKK2, showing tyrosine autophosphorylation and ATP-contacting residue K44 regulate substrate specificity for IκBα phosphorylation during NF-κB activation.

The paper analyzes lion diet in Tsavo, Kenya, finding that lions disproportionately consume endangered hirola and Grevys zebra despite their low population sizes.

The paper studies predator interactions at elephant carcasses using remote cameras, finding interference competition among terrestrial predators and unique feeding behaviors at aquatic interfaces.

The study examines how wolf presence affects deer behavior in areas with and without wolves, finding that deer in wolf-present areas show reduced activity and increased vigilance in dense vegetation, while naive deer in wolf-absent areas do not respond similarly.

The paper develops a stochastic model of histone dynamics at the replication fork, showing that differential diffusivity explains histone inheritance patterns and predicts epigenomic patterns observed in experiments.

This study identifies priority landscapes in India for biodiversity conservation and ecosystem services that align with human well-being, finding that current protected areas cover only 15% of these regions.

This study shows that UPF2 binding reduces UPF1's RNA affinity, causing RNA release through an allosteric effect rather than direct competition.

This study identifies a direct interaction between TTP and DCP2 involving intrinsically disordered regions that influences ARE-mRNA stability.

This study shows that non-stimulatory cargo-free particles enhance phagocytic ability in macrophages and neutrophils, leading to faster bacterial clearance.

This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

The paper identifies BM-derived CD45+EpCAM+ cells that contribute to thymic stroma and TEC maintenance, challenging the notion that these cells originate solely from endoderm.

This study systematically surveys the evolution of DNA methyltransferases across different lineages, finding increased sequence conservation and complexity in vertebrates.

The paper identifies guanabenz and sephin1 as new allosteric modulators of ASIC3 through in silico screening of FDA-approved drugs and electrophysiological validation.

This study investigates the role of the complement pathway in diabetic retinopathy, finding increased activation of the alternative pathway and co-localization of CFH with microglial cells.

This study investigates the structural and material properties of hyaluronan from naked mole-rats, revealing unique folded structures and gel-forming capabilities that may contribute to their cancer resistance and skin elasticity.

This study derives analytic expressions for helicase velocity and processivity, showing processivity increases with force and reveals T7 is a weakly active helicase with high back-stepping probability.

The paper develops a stochastic model to explain how molecular chaperones maximize native state production rates by driving substrates out of equilibrium, reconciling conflicting experimental results on ribozyme and protein folding.

The paper develops a polymer physics-based theory to assess protein collapsibility using contact maps, showing that beta-sheet proteins are more collapsible than alpha-helical ones and explaining the origin of multi-domain proteins.