Loss of Skeletal Muscle Pyruvate Dehydrogenase Induces Lactic Acidosis and Adaptive Anaplerotic Compensation via Pyruvate-Alanine Cycling and Glutaminolysis
K. Gopal, A. M. Abdualkader, X. Li, A. A. Greenwell, Q. G. Karwi, C. Saed, G. M. Uddin, A. M. Darwesh, K. L. Jamieson, T. R. Altamimi, R. Kim, F. Eaton, J. M. Seubert, G. D. Lopaschuk, J. R. Ussher, R. Al Batran
This study shows that loss of skeletal muscle pyruvate dehydrogenase causes lactic acidosis and early death, but high-fat diets can mitigate these effects.
bioRxiv · May 10, 2023 · PreprintCell Biology