Author

G. McFadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. M. Rahman· 3 shared A. D. Gutierrez-Jensen· 2 shared B. L. Jacobs· 2 shared P. J. Esteves· 2 shared A. A. Pinto· 1 shared A. Agueda-Pinto· 1 shared A. Everts· 1 shared A. Lemos de Matos· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

M. M. Rahman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Effect of exportin 1/XPO1 nuclear export pathway inhibition on coronavirus replication.

M. M. Rahman, B. Estifanos, H. L. Glenn, A. D. Gutierrez-Jensen, K. V. Kibler, Y. Li, B. L. Jacobs, G. McFadden, B. G. Hogue

This study investigates how inhibiting the XPO1 nuclear export pathway affects coronavirus replication in different cell lines, finding varied effects on MHV and SARS-CoV-2.

Viruses · Feb 18, 2025Peer-reviewedMicrobiology

A novel anti-cancer therapy with nuclear export inhibitor Selinexor in combination with oncolytic myxoma virus

M. M. Rahman, F. v. Oosterom, J. A. Enow, M. Hossain, A. D. Gutierrez-Jensen, M. Cashen, A. Everts, K. Lowe, J. Kilbourne, J. Daggett-Vondras, T. L. Karr, G. McFadden

This study shows that combining Selinexor with oncolytic myxoma virus enhances virus replication and cancer cell killing in vitro and in vivo.

bioRxiv · Oct 31, 2022 · PreprintMicrobiology

Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes virus countermeasures

A. A. Pinto, L. Q. Alves, F. Neves, G. McFadden, B. L. Jacobs, F. Castro, M. M. Rahman, P. J. Esteves

The paper shows that necroptosis pathway components are lost in multiple mammalian lineages, correlating with viral adaptations that counteract this host defense mechanism.

bioRxiv · Jun 8, 2021Evolutionary Biology

Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites

N. J. KATRIS, Y. YAMARYO-BOTTE, J. JANOUSKOVEC, S. SHUNMUGAM, C.-S. ARNOLD, A. S. P. YANG, A. VARDAKIS, R. STEWART, R. SAUERWEIN, G. McFADDEN, C. J. TONKIN, M.-F. CESBRON-DELAUW, C. Y. BOTTE

The paper investigates the rapid lipid second messenger dynamics in Toxoplasma tachyzoites, showing how cGMP signaling regulates membrane lipid turnover and coordinates invasion and egress.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

Genetic characterization of a recombinant myxoma virus leap into the Iberian hare (Lepus granatensis)

A. Agueda-Pinto, A. Lemos de Matos, M. Abrantes, S. Kraberger, M. A. Risalde, C. Gortazar, G. McFadden, A. Varsani, P. J. Esteves

The paper reports a new Myxoma virus strain (MYXV Toledo) in Iberian hares, characterized by three disrupted genes and a recombinant region with novel poxviral genes.

bioRxiv · May 1, 2019Microbiology