Methanogenesis inhibition remodels microbial fermentation and stimulates acetogenesis in ruminants
Gaofeng Ni, Min Wang, Nicola D. Walker, Stefan Muetzel, Oliver Schmidt, André Fischer, René T. Stemmler, Pok Man Leung, Xiumin Zhang, Qiushuang Li, Surbhi Jain, Marion Jespersen, Rhys Grinter, Stephen D. J. Archer, David Pacheco, , Chris Greening
This study shows that 3-NOP reduces methane emissions in ruminants by altering microbial communities and fermentation pathways, but limits productivity gains due to shifts in hydrogen-cycling microbes.
Proceedings of the National Academy of Sciences · Oct 6, 2025Peer-reviewedMicrobiology