G. Mollaoglu

Targeting macrophages with CAR-T cells delays solid tumor progression and enhances anti-tumor immunity

This study shows that CAR-T cells targeting macrophages delay tumor growth and improve survival in mouse models of solid tumors by enhancing anti-tumor immunity.

P53 is a direct regulator of the immune co-stimulatory molecule CD80

This study identifies CD80 as a direct target of P53, showing that P53 loss reduces CD80 expression and impairs T cell priming in colorectal cancer.