Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune composition
M. Dhainaut, S. A. Rose, G. Akturk, A. Wroblewska, E. Sook Park, S. R. Nielsen, M. Buckup, V. Roudko, L. Pia, J. Le Berichel, A. Bektesevic, B. H. Lee, A. Baccarini, N. Bhardwaj, A. H. Rahman, , B. D. Brown
Perturb-map enables spatial CRISPR screening in tumors, identifying genes that regulate immune composition by mapping gene knockouts and their effects on the tumor microenvironment.
bioRxiv · Jul 13, 2021 · PreprintImmunology