Augmenter of Liver Regeneration Regulates Cellular Iron by Modulating Mitochondrial Transport of ATP-Binding Cassette B8
H. Ardehali, H.-C. Chang, J. S. Shapiro, X. Jiang, G. Senyei, T. Sato, K. Sawicki
This study shows that ALR loss impairs mitochondrial ABCB8 import, reduces Fe/S cluster maturation, and increases cellular iron through the IRP-IRE system.
bioRxiv · Nov 30, 2020Cell Biology