Author

H.-C. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 3 Bioengineering· 2 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

H. Ardehali· 3 shared J. S. Shapiro· 3 shared G. Kim· 2 shared S. Senapati· 2 shared T. Sato· 2 shared T. Shi· 2 shared Y. Wang· 2 shared A. Akrami· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCell Biology

H. Ardehali

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Author profile →

11 papers

Recent·Most cited

Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures

J. Johnston, H. Jeon, Y. Y. Choi, G. Kim, T. Shi, C. Khong, H.-C. Chang, N. V. Myung, Y. Wang

This paper develops a 3D culture platform using piezoelectric nanofibrous scaffolds with acoustic stimulation to significantly enhance small extracellular vesicle production.

bioRxiv · Apr 12, 2024Bioengineering

A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

H. Sharma, V. Yadav, A. Burchett, T. Shi, S. Senapati, M. Datta, H.-C. Chang

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.

bioRxiv · Mar 10, 2024Cancer Biology

Detection of EGFR and its Activity State in Plasma CD63-EVs from Glioblastoma Patients: Rapid Profiling using an Anion Exchange Membrane Sensor

N. Maniya, S. Kumar, J. L. Franklin, J. N. Higginbotham, A. M. Scott, H. K. Gan, R. J. Coffey, S. Senapati, H.-C. Chang

This paper introduces a novel immunoassay for detecting EGFR and its activity state in plasma CD63-EVs from glioblastoma patients, achieving high sensitivity and specificity for early detection.

bioRxiv · Oct 16, 2023 · PreprintCancer Biology

DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization

P. J. Stanczyk, Y. Tatekoshi, J. S. Shapiro, K. Nayudu, Y. Chen, Z. Zeilber, M. Schipma, A. De Jesus, A. Mahmoodzadeh, A. Akrami, H.-C. Chang, H. Ardehali

This study shows that SNRK regulates cardiac hypertrophy and DNA damage by modulating actin polymerization through its interaction with DSTN.

bioRxiv · Jul 14, 2023Cell Biology

Chiral Graphene Quantum Dots Enhanced Drug Loading into Exosomes

Y. Zhang, Y. Zhu, G. Kim, C. Wang, R. Zhu, X. Lu, H.-C. Chang, Y. Wang

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

bioRxiv · Jan 20, 2023 · PreprintBioengineering

Auxin Plays a Role in the Adaptation of Rice to Anaerobic Germination and Seedling Establishment

K.-W. Lee, J. J. W. Chen, C.-S. Wu, H.-C. Chang, H.-Y. Chen, H.-H. Kuo, Y.-S. Lee, Y.-L. Chang, H.-C. Chang, S.-Y. Shiuea, Y.-C. Wu, Y. C. Ho, P.-W. Chen

This study shows that auxin accumulation under submergence inhibits rice root and leaf growth but promotes coleoptile elongation, with miR167-ARF-GH3 pathway regulating IAA levels to affect anaerobic germination tolerance.

bioRxiv · May 5, 2022Plant Biology

Laser Ablation and Fluid Flows Show a Single Force Mechanism Governs Spindle Positioning

H.-Y. Wu, G. Kabacaoglu, E. Nazockdast, H.-C. Chang, M. J. Shelley, D. J. Needleman

The paper develops two techniques to study subcellular forces and applies them to show cortical pulling forces govern centrosome-related behaviors in C. elegans embryos.

bioRxiv · Nov 21, 2021 · PreprintBiophysics

Aging is associated with increased brain iron through brain-derived hepcidin expression

H. Ardehali, T. Sato, J. S. Shapiro, H.-C. Chang, R. A. Miller

This study shows that aging increases brain iron levels through elevated local hepcidin expression, leading to reduced iron export and accumulation in both cytosolic and mitochondrial compartments.

bioRxiv · Sep 6, 2021Cell Biology

Augmenter of Liver Regeneration Regulates Cellular Iron by Modulating Mitochondrial Transport of ATP-Binding Cassette B8

H. Ardehali, H.-C. Chang, J. S. Shapiro, X. Jiang, G. Senyei, T. Sato, K. Sawicki

This study shows that ALR loss impairs mitochondrial ABCB8 import, reduces Fe/S cluster maturation, and increases cellular iron through the IRP-IRE system.

bioRxiv · Nov 30, 2020Cell Biology

Dynamic-ultrastructural cell volume (3D) correlative microscopy facilitated by intracellular fluorescent nanodiamonds as multi-modal probes

N. Prabhakar, I. Belevich, M. Peurla, X. Heiligenstein, H.-C. Chang, C. Sahlgren, E. Jokitalo, J. Rosenholm

This paper introduces a method using fluorescent nanodiamonds for 3D correlative light and electron microscopy to align multi-modal cell imaging data.

bioRxiv · Oct 29, 2019Cell Biology

Mechanistic and compositional studies of the autophagy-inducing areca nut ingredient

Y.-C. Liu, C.-T. Chiu, S.-Y. Liu, C.-Y. Yen, M.-T. Tsai, H.-C. Chang, M.-H. Lin

This study investigates the mechanism and composition of ANE 30-100K, showing it induces autophagy via caveolin-mediated endocytosis and proteasome, and is primarily composed of carbohydrates.

bioRxiv · Jun 20, 2019Cancer Biology