T. Sato

Integration of Proxy Intermediate Omics traits into a Nonlinear Two-Step model for accurate phenotypic prediction

The paper proposes a nonlinear two-step model integrating proxy intermediate omics traits to improve phenotypic prediction in soybean, showing better accuracy than linear models.

Survivability and Life Support in Sealed Mini-Ecosystems with Simulated Planetary Soils

The paper explores sustainable life-support systems for space by simulating Earth ecosystems, identifying challenges like moisture and temperature, and highlighting microbial roles in ecosystem stability.

ZIP13 regulates lipid metabolism by changing intracellular iron and zinc balance

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

Deep Visual Proteomics advances human colon organoid models by revealing a switch to an in vivo-like phenotype upon xenotransplantation

The paper uses Deep Visual Proteomics to show that human colon organoids switch to an in vivo-like phenotype after xenotransplantation.

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.

Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration

This study compares protein adsorption by PMMA and PES hemodiafilters in OL-HDF, finding PMMA adsorbs more inflammatory proteins like IL-6 and beta-2 microglobulin.

Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against ATL

This study shows that mismatch between viral antigen epitopes and T-cell responses in HTLV-1 infection may reduce immunotherapy effectiveness against ATL.

JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis

This study uses scRNA-seq to show JAK/STAT signaling creates unique regenerative cell states in ulcerative colitis, altering normal tissue replenishment patterns.

Nuclear membrane protein Bqt4 maintains nuclear envelope integrity by recruiting phosphatidic acid

This study identifies Bqt4 as an inner nuclear membrane protein that recruits phosphatidic acid to maintain nuclear envelope integrity in fission yeast.

Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.

Genome analysis of the Jomon dogs reveals the oldest domestic dog lineage in Eastern Eurasia

This study analyzes ancient Jomon dog genomes to reveal their lineage and contribution to modern dog genomes, finding they are one of the oldest East Eurasian lineages with significant genetic influence.

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

Discovery of an isoflavone oxidative catabolic pathway in legume root microbiota

The paper identifies an oxidative isoflavone catabolic pathway in legume root microbiota, revealing its role in detoxifying isoflavones and shaping microbiota interactions.

Skin surface biomarkers are associated with future development of atopic dermatitis in children with family history of allergic disease

The plasma degradome reflects later development of NASH fibrosis after liver transplant

The paper identifies a plasma degradome profile predictive of post-liver transplant NASH fibrosis using peptide analysis in human and mouse samples.

A fungal secondary metabolism gene cluster enables mutualist-pathogen transition in root endophyte Colletotrichum tofieldiae

The paper identifies a fungal gene cluster in Colletotrichum tofieldiae that enables lifestyle transition between mutualism and pathogenesis by modulating host nutrient uptake and ABA pathways.

Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

The paper investigates the role of circadian clocks in liver and skeletal muscle in glucose metabolism, finding that inter-organ communication is necessary for systemic glucose homeostasis.

Fibrosis resolution in the mouse liver: role of Mmp12 and potential role of Calpain 1/2

This study examines the role of MMP12 and Calpain 1/2 in liver fibrosis resolution using a mouse model, finding that MMP12 inhibition delays resolution and Calpains may contribute to protein degradation.

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

This paper describes the discovery of S-217622, an oral non-covalent SARS-CoV-2 3CL protease inhibitor showing antiviral activity and favorable pharmacokinetics in preclinical studies.

The central clock suffices to drive the majority of circulatory metabolic rhythms

The study shows that the central clock, via Syt10-expressing neurons, drives most circulatory metabolic rhythms and rescues glucose intolerance, highlighting its role in circadian communication.

Partial prevention of glucocorticoid-induced osteocyte deterioration with osteocrin gene therapy

This study tests osteocrin gene therapy to prevent glucocorticoid-induced osteocyte damage in mice, finding partial protection against osteocyte death but not all skeletal effects.

Phosphorus is a critical factor of the in vitro monoxenic culture method for awide range of arbuscular mycorrhizal fungi culture collections

This study identifies phosphorus concentration as a critical factor for mycorrhizal formation in in vitro monoxenic cultures of arbuscular mycorrhizal fungi.

Aging is associated with increased brain iron through brain-derived hepcidin expression

This study shows that aging increases brain iron levels through elevated local hepcidin expression, leading to reduced iron export and accumulation in both cytosolic and mitochondrial compartments.

Machine-learning-guided library design cycle for directed evolution of enzymes: the effects of training data composition on sequence space exploration

This study shows that ML-guided directed evolution can lead to different enzyme variants depending on the presence of a highly positive variant in training data, achieving similar activity improvements.

Internal and external features of wild birds after collisions without apparent trauma in Japan

The paper examines internal and external features of wild birds after collisions without visible trauma, finding kidney discoloration and anterior lobe extension associated with collisions.

Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids

This study shows that threonine phosphorylation in EGFR's JM domain switches its function from kinase activation dimers to scaffolding oligomers, influenced by membrane lipids.

Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in Candida albicans by glucose in urine

This study shows that high glucose levels in urine promote Candida albicans growth and reduce susceptibility to azoles and 5-fluorocytosine.

Simple amplicon sequencing library preparation for plant root microbial community profiling

The paper develops a simplified high-throughput method for 16S rRNA gene amplicon sequencing of plant root microbiota, showing improved microbial diversity capture compared to standard methods.