B. E. Clifton

This paper engineers a non-site-specific m6A RNA methyltransferase, SUPREM, with improved efficiency, thermostability, and methylation activity compared to M.EcoGII.

The paper identifies ultrahigh-affinity transport proteins in SAR11 bacteria, revealing their molecular mechanisms and global patterns of nutrient uptake in the ocean.

This paper investigates how trimerization and a C-terminal extension optimized the catalytic activity of cyclohexadienyl dehydratase through evolutionarily metastable oligomeric states.

This study uses experimental evolution to show that loss of the tRNA modification m1G37 in E. coli is tolerated via compensatory mutations in the proline-tRNA ligase gene proS, revealing ProRS as a gatekeeper of translational accuracy.

The paper explores how network topology in autocatalytic RNA reaction networks affects Darwinian properties like variation, reproduction, and heredity, identifying trade-offs between these traits.

The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.