NeuroscienceThe FASEB JournalPeer-reviewed
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC--derived microglia
Thomas M. Piers, Katharina Cosker, Anna Mallach…·Jennifer M. Pocock
This study shows that TREM2 loss-of-function variants in human iPSC-derived microglia impair metabolic switching and PPARγ/p38MAPK signaling, affecting β-Amyloid phagocytosis.
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