Cullin1 represses systematic inflammasome activation by binding and catalyzing NLRP3 ubiquitination
Pin Wan, Qi Zhang, Weiyong Liu, Yaling Jia, Tianci Wang, Wenbiao Wang, Pan Pan, Ge Yang, Qi Xiang, Siyu Huang, Qingyu Yang, Wei Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
This study identifies CUL1 as a repressor of NLRP3 inflammasome activation by ubiquitinating NLRP3, showing its role in controlling immune responses under physiological and inflammatory conditions.
bioRxiv · Mar 27, 2018 · PreprintImmunology